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Protein tyrosine phosphatase 1B inhibitory activities of compounds isolated from Polygonum cuspidatum
Author(s) -
Luyen Le Hong,
Quan Pham Minh,
Hung Nguyen Phi
Publication year - 2019
Publication title -
vietnam journal of chemistry
Language(s) - English
Resource type - Journals
eISSN - 2572-8288
pISSN - 0866-7144
DOI - 10.1002/vjch.201900057
Subject(s) - emodin , anthraquinones , ursolic acid , chemistry , ic50 , traditional medicine , inhibitory postsynaptic potential , stereochemistry , biochemistry , in vitro , biology , chromatography , botany , medicine , neuroscience
In the search for new natural PTP1B inhibitory compounds from medicinal plants, two 9,10‐anthraquinones were isolated and structurally identified as physcion ( 1 ) and emodin ( 2 ) from the alcoholic extract of the root of Polygonum cuspidatum . Chemical structures of these isolates were identified by interpretation of spectroscopic data ( 1 H, 13 C NMR and MS) as well as comparing with reported literatures. Compounds 1 – 2 possessed inhibitory activity on PTP1B enzyme with IC 50 values of 26.1 ± 0.7 and 13.3 ± 0.4 μM, respectively. Ursolic acid was used as positive control showing an IC 50 value of 3.5 ± 0.2 μM in this assay. This result reveals that these 9,10‐anthraquinones might be considered as new natural compounds for development of antidiabetic agents.