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Synthesis of Valsartan as drug for the treatment of hypertension
Author(s) -
Van Chien Tran,
Anh Nguyen The,
Thao Tran Thi Phuong,
Phuong Le Dac,
Tham Pham Thi,
Tung Nguyen Quang,
Van Loc Tran
Publication year - 2019
Publication title -
vietnam journal of chemistry
Language(s) - English
Resource type - Journals
eISSN - 2572-8288
pISSN - 0866-7144
DOI - 10.1002/vjch.201900038
Subject(s) - valsartan , yield (engineering) , ring (chemistry) , chemistry , tetrazole , drug , combinatorial chemistry , lewis acids and bases , pharmacology , organic chemistry , stereochemistry , medicine , catalysis , materials science , blood pressure , metallurgy
Abstract The synthesis of valsartan ( 1 ), one of the most currently used pharmaceutical agent in antihypertensive therapy, was described through five steps in an overall yield of 54 % starting from 4’‐methyl‐2‐cyanobiphenyl ( 2 ). The key step involved tetrazole ring formation catalyzed by Lewis acid. The structures of synthesized compounds were confirmed by means of NMR and MS spectroscopíe.