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Antimicrobacterial xanthones from Garcinia mackeaniana leaves
Author(s) -
Ha Nguyen Thi Thu,
Van Cuong Pham,
Anh Le Thi Tu,
Tra Nguyen Thanh,
Cham Ba Thi,
Son Ninh The
Publication year - 2020
Publication title -
vietnam journal of chemistry
Language(s) - English
Resource type - Journals
eISSN - 2572-8288
pISSN - 0866-7144
DOI - 10.1002/vjch.2019000183
Subject(s) - mangiferin , phytochemical , xanthone , garcinia , traditional medicine , chemistry , clusiaceae , staphylococcus aureus , stereochemistry , bacteria , biology , chromatography , medicine , genetics
A phytochemical study of the EtOAc extract of Garcinia mackeaniana leaves has resulted in the isolation and determination of five xanthones, consisting of norathyriol ( 1 ), mangiferin ( 2 ), allanxanthone C ( 3 ), garcinone E ( 4 ), and bannanxanthone E ( 5 ). The structures of these xanthones have been determined by NMR‐spectra and MS spectroscopic data. These isolated compounds were separated from G. mackeaniana species for the first time. In the antimicrobacterial assay against the growth of bacterium Staphylococcus aureus , compounds 3‐4 showed the significant IC 50 values of 5.41, and 4.29 μM/mL, respectively.