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Study on the synthesis of Exemestane
Author(s) -
Tuan Cao Duc,
Kim Loan Vu Thi,
Trung Trinh Hien,
Van Hung Nguyen,
Van Thuc Pham
Publication year - 2018
Publication title -
vietnam journal of chemistry
Language(s) - English
Resource type - Journals
eISSN - 2572-8288
pISSN - 0866-7144
DOI - 10.1002/vjch.201800073
Subject(s) - exemestane , medicine , traditional medicine , aromatase , cancer , breast cancer
Exemestane, a 3 rd ‐generation aromatase inhibitor, has been approved by FDA for the treatment of advanced breast cancer in postmenopausal women since 1995 and its patent was expired in 2015. Since the approval, Exemestane has been widely used in breast cancer patients and is shown to have good clinical effects. There are several published synthesis methods of Exemestane but there is not any such report in Viet Nam. Herein, we describe the two‐step method for the synthesis of Exemestane from the commercial available compound, androst‐4‐ene‐3,17‐dione. The total yield of the synthesized Exemestane is 27.12 %. The structure of Exemestane and intermediate products were elucidated by MS and NMR spectroscopies.