Synthesis and biological activities of organoaluminum steroids | Zendy

Dzhemilev Usein M. | Zendy; D'Yakonov Vladimir A. | Zendy; Tuktarova Regina A. | Zendy; Gloriozova Tatyana A. | Zendy; Dzhemileva Lilya U. | Zendy; Terent'Ev Alexander O. | Zendy; Dembitsky Valery M. | Zendy

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Synthesis and biological activities of organoaluminum steroids

Author(s) -

Dzhemilev Usein M.,

D'Yakonov Vladimir A.,

Tuktarova Regina A.,

Gloriozova Tatyana A.,

Dzhemileva Lilya U.,

Terent'Ev Alexander O.,

Dembitsky Valery M.

Publication year - 2018

Publication title -

vietnam journal of chemistry

Language(s) - English

Resource type - Journals

eISSN - 2572-8288

pISSN - 0866-7144

DOI - 10.1002/vjch.201800066

Subject(s) - antiprotozoal , yield (engineering) , chemistry , catalysis , steroid , certainty , organic chemistry , combinatorial chemistry , biochemistry , in vitro , mathematics , materials science , geometry , hormone , metallurgy

This review presents the synthesis of organoaluminum steroids (OAS) using catalytic cycloalumination of vinylcholestane and/or allylcholestane derivatives with Et 3 Al catalyzed by Cp 2 ZrCl 2 which gives aluminacyclopentanes in a yield of about 90 %. Biological activity of synthesized organoaluminum steroids was determined with an aid of PASS program. Organoaluminum steroids showed antiprotozoal, antihypercholesterolemic, and antieczematic activity with a certainty from 78 to 92 %.

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