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Synthesis and biological activities of organoaluminum steroids
Author(s) -
Dzhemilev Usein M.,
D'Yakonov Vladimir A.,
Tuktarova Regina A.,
Gloriozova Tatyana A.,
Dzhemileva Lilya U.,
Terent'Ev Alexander O.,
Dembitsky Valery M.
Publication year - 2018
Publication title -
vietnam journal of chemistry
Language(s) - English
Resource type - Journals
eISSN - 2572-8288
pISSN - 0866-7144
DOI - 10.1002/vjch.201800066
Subject(s) - antiprotozoal , yield (engineering) , chemistry , catalysis , steroid , certainty , organic chemistry , combinatorial chemistry , biochemistry , in vitro , mathematics , materials science , geometry , hormone , metallurgy
Abstract This review presents the synthesis of organoaluminum steroids (OAS) using catalytic cycloalumination of vinylcholestane and/or allylcholestane derivatives with Et 3 Al catalyzed by Cp 2 ZrCl 2 which gives aluminacyclopentanes in a yield of about 90 %. Biological activity of synthesized organoaluminum steroids was determined with an aid of PASS program. Organoaluminum steroids showed antiprotozoal, antihypercholesterolemic, and antieczematic activity with a certainty from 78 to 92 %.