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Cyclopeptides from marine actinomycete Streptomyces sp. G261
Author(s) -
Danh Cao Duc,
Dao Phi Thi,
Huong Doan Thi Mai,
Thach Tran Dang,
Anh Nguyen Mai,
Minh Le Thi Hong,
Anh Tran Tuan,
Van Cuong Pham
Publication year - 2018
Publication title -
vietnam journal of chemistry
Language(s) - English
Resource type - Journals
eISSN - 2572-8288
pISSN - 0866-7144
DOI - 10.1002/vjch.201800049
Subject(s) - bacillus cereus , streptomyces , antimicrobial , candida albicans , enterococcus faecalis , strain (injury) , microbiology and biotechnology , pseudomonas aeruginosa , chemistry , stereochemistry , bacteria , biology , staphylococcus aureus , genetics , anatomy
According to the results from our screening program, the EtOAc extract of a Streptomyces sp. (strain G261) collected in Cu Lao Cham – Quang Nam showed antimicrobial activity against Enterococcus faecalis , Bacillus cereus , Pseudomonas aeruginosa and Candida albicans . Seven secondary metabolites Cyclo‐(Leu‐Pro) ( 1 ), Cyclo‐(Pro‐Gly) ( 2 ), Cyclo‐(Pro‐Ala) ( 3 ), Cyclo‐(Leu‐Tyr) ( 4 ), Cyclo‐(Pro‐Tyr) ( 5 ), and Cyclo‐ trans ‐4‐OH‐(Pro‐Phe) ( 6 ) were isolated from the cultures broth of Streptomyces (strain G261). Their structures were determined by MS and 2D NMR spectroscopic analysis, as well as by comparison with reported data in literature.