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Secondary metabolites from the marine‐derived fungus Paraconiothyrium sp. VK‐13
Author(s) -
Quang Tran Hong,
Nhiem Nguyen Xuan,
Tai Bui Huu,
Yen Pham Hai,
Dung Duong Thi,
Ngan Nguyen Thi Thanh,
Le Tuan Anh Hoang,
Van Minh Chau,
Van Kiem Phan
Publication year - 2018
Publication title -
vietnam journal of chemistry
Language(s) - English
Resource type - Journals
eISSN - 2572-8288
pISSN - 0866-7144
DOI - 10.1002/vjch.201800026
Subject(s) - fungus , fermentation , stereochemistry , marine fungi , ethyl acetate , chemistry , chemical structure , biology , botany , organic chemistry
Chemical investigation of a fermentation culture of the marine endophytic fungus Paraconiothyrium sp. VK‐13 resulted in the isolation of five compounds, including a new phenolic compound, 1‐(2,5‐dihydroxyphenyl)‐1‐oxobutan‐3‐yl acetate ( 1 ) and four known metabolites, 1‐(2,5‐dihydroxyphenyl)‐2‐buten‐1‐one ( 2 ), 3,7‐dimethyl‐1,8‐dihydroxy‐6‐methoxyisochroman ( 3 ), modiolides A ( 4 ) and B ( 5 ). Their chemical structures were identified based on 1D, 2D NMR, and MS spectroscopic analysis and comparison with the data reported previously in the literature. All the isolated compounds were reported for the first time from the genus Paraconiothyrium .