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Chemical constituents from the ethyl acetate extract of the stems of Macaranga balansae Gagnep.
Author(s) -
Thang Pham Toan,
Thoa Ha Thi,
Giap Tran Huu,
Thanh Le Nguyen,
Hang Nguyen Thi Minh,
Oanh Vu Thi Kim,
Huong Tran Thu,
Huong Doan Thi Mai,
Van Cuong Pham
Publication year - 2018
Publication title -
vietnam journal of chemistry
Language(s) - English
Resource type - Journals
eISSN - 2572-8288
pISSN - 0866-7144
DOI - 10.1002/vjch.201800022
Subject(s) - ellagic acid , ethyl acetate , traditional medicine , chemistry , protocatechuic acid , antimicrobial , clusiaceae , euphorbiaceae , genus , botany , antioxidant , biology , organic chemistry , medicine , polyphenol
The genus Macaranga , one of the largest genera of the Euphorbiaceae family has approximately 300 species distributed in the tropical regions. Plants of this genus displayed various bioactivities such as antioxidant, antitumor and antimicrobial effects. Macaranga balansae Gagnep. is an endemic plant in Vietnam, that ethyl acetate extract showed cytotoxicity to cancer cell line. In this article, we report the isolation and structural elucidation of six known compounds from the ethyl acetate extract including (‐)‐dehydroxycubebin ( 1 ) , trans ‐coniferyl aldehyde ( 2 ), 3,3',4'‐tri‐O‐methyl ellagic acid ( 3 ), stigmastane 3 β ,5 α ,6 β ‐triol ( 4 ), 2,3‐dihydroxy‐1‐(4’‐hydroxy‐3’‐methoxyphenyl) propan‐1‐one ( 5 ), and protocatechuic acid ( 6 ). To the best of our knowledge, compounds 1 ‐ 5 were isolated from Macaranga genus for the first time.