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Synthesis of novel artemisinin–triazole hybrids
Author(s) -
Giang Le Nhat Thuy,
Anh Dang Thi Tuyet,
Phuong Hoang Thi,
Thanh Nguyen Ha,
Van Tuyen Nguyen
Publication year - 2018
Publication title -
vietnam journal of chemistry
Language(s) - English
Resource type - Journals
eISSN - 2572-8288
pISSN - 0866-7144
DOI - 10.1002/vjch.201800007
Subject(s) - artemisinin , triazole , chemistry , propargyl , cancer cell lines , combinatorial chemistry , stereochemistry , click chemistry , hybrid , organic chemistry , plasmodium falciparum , cancer cell , catalysis , biology , cancer , botany , malaria , immunology , genetics
Several substituted triazole–artemisinin hybrids were synthesized based on ‘click’ chemistry between propargyl‐substituted derivatives and artemisinin containing a 2‐hydroxypropane unit. The structures of all obtained compounds were confirmed by means of IR, NMR, and MS spectroscopy. Four new hybrids were evaluated as cytotoxic agents, revealing an interesting anticancer activity of 1‐(4‐(3‐Aminophenyl)‐1 H ‐1,2,3‐triazol‐1‐yl)‐3‐(((3 R ,6 R ,8a S ,9 R ,10 S ,12 R ,12a R )‐3,6,9‐trimethyl‐decahydro‐12 H ‐3,12‐epoxy[1,2]dioxepino[4,3‐ i ]isochromen‐10‐yl)oxy)propan‐2‐ol compound in KB and HepG2 cancer cell lines.