Open AccessCover Picture: Perspectives on liquid biopsy for label‐free detection of “circulating tumor cells” through intelligent lab‐on‐chips (View 3/2020)
Author(s) -
Miccio Lisa,
Cimmino Flora,
Kurelac Ivana,
Villone Massimiliano M.,
Bianco Vittorio,
Memmolo Pasquale,
Merola Francesco,
Mugnano Martina,
Capasso Mario,
Iolascon Achille,
Maffettone Pier Luca,
Ferraro Pietro
Publication year - 2020
Publication title -
view
Language(s) - English
Resource type - Reports
eISSN - 2688-268X
pISSN - 2688-3988
DOI - 10.1002/viw2.56
Subject(s) - liquid biopsy , circulating tumor cell , phase contrast microscopy , computer science , cancer detection , sorting , cover (algebra) , artificial intelligence , cancer , biomedical engineering , medicine , engineering , metastasis , physics , mechanical engineering , programming language , optics
In article number 20200034, Pietro Ferraro and co‐workers emphasize that early detection in cancer diseases is a key issue. The current state of the art of technology could allow a great opportunity for this purpose, to develop systems for detecting circulating cancer cells (CTC) in the blood. The challenge is to recognize and classify cancer cells and detect them non‐invasively through a lab‐on‐chip device as they flow. Single‐cell holographic phase contrast tomography offers the possibility in the real world to detect CTC in a label‐free mode by means of morphological analyzes when combined with artificial intelligence (AI). The cover summarizes and depicts the main concepts and the technological ingredients necessary to achieve such an ambitious goal, namely the recognition and sorting of cells, 3D‐imaging by microscope and complete morphological analysis of 3D‐phase‐contrast tomograms by AI tools.