Open AccessInside Front Cover: Design of polymers for siRNA delivery: Recent progress and challenges (View 3/2021)
Author(s) -
Wang Hui,
Zhang Song,
Lv Jia,
Cheng Yiyun
Publication year - 2021
Publication title -
view
Language(s) - English
Resource type - Reports
eISSN - 2688-268X
pISSN - 2688-3988
DOI - 10.1002/viw2.146
Subject(s) - rna interference , small interfering rna , gene delivery , genetic enhancement , translation (biology) , intracellular , nanotechnology , computational biology , medicine , biology , microbiology and biotechnology , transfection , materials science , gene , rna , messenger rna , genetics
RNAi‐mediated gene therapy is gradually becoming a conventional approach for the treatment of various diseases. One of the major challenges for clinical translation of RNAi is to efficiently deliver siRNA into targeted tissues and cells. Herein, in article number 20200026 Yiyun Cheng, Jia Lv and their co‐workers have reviewed recent advances in the design of functional polymers to overcome the multiple extracellular and intracellular barriers during siRNA delivery in vitro and in vivo , and provided perspectives for future siRNA delivery systems.