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A proposed medication score for long‐term trials of treatment of canine atopic dermatitis sensu lato
Author(s) -
Saridomichelakis Manolis N.,
Favrot Claude,
Jackson Hilary A.,
Bensignor Emmanuel,
Prost Christine,
Mueller Ralf S.
Publication year - 2021
Publication title -
veterinary record
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.261
H-Index - 99
eISSN - 2042-7670
pISSN - 0042-4900
DOI - 10.1002/vetr.19
Subject(s) - atopic dermatitis , medicine , prednisone , methylprednisolone , clinical trial , regimen , dermatology
Background : The use of concurrent medications is necessary in trials of treatment of canine atopic dermatitis. Our aim was to use the best available evidence to construct and then to validate a medication score (MS) formula that will estimate the impact of concurrent medications on trial outcomes. Methods : Trials of 15 interventions were scrutinized to find those that were consistent in terms of specific medication, administration route and dosage regimen. A MS was constructed in five steps, starting from assigning a score of 1 for each day on oral prednisone, prednisolone or methylprednisolone at 0.5–1.0 mg/kg. The MS score was validated using the clinical records of 35 dogs with atopic dermatitis that had been treated for a period of 12 ± 2 weeks with six of these medications and compared with a previously published non‐validated MS. Results : A MS could be assigned to eight treatments, six of which had been administered to the 35 dogs. A positive correlation was seen with the previously published MS and a negative correlation with changes in lesional and pruritus scores. Conclusion : This MS may be a useful tool in new studies evaluating the efficacy of treatments in canine atopic dermatitis