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Ultrasonographic measurement of fetal nasal bone in a low‐risk population at 19–22 gestational weeks
Author(s) -
Gámez F.,
Ferreiro P.,
Salmeán J. M.
Publication year - 2004
Publication title -
ultrasound in obstetrics and gynecology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.202
H-Index - 141
eISSN - 1469-0705
pISSN - 0960-7692
DOI - 10.1002/uog.929
Subject(s) - nasal bone , medicine , fetus , trisomy , gestation , hypoplasia , gestational age , population , obstetrics , pregnancy , anatomy , biology , environmental health , genetics
Objective To determine the potential value of sonographic measurement of fetal nasal bone at 19–22 weeks' gestation in screening for trisomy 21 in a low‐risk population. Methods The fetal nasal bone was measured in a mid‐sagittal view in 2035 fetuses at 19–22 weeks' gestation. A reference range was constructed and the measurements in fetuses with trisomy 21 were compared to the normal group. Results The fetal profile was successfully examined in 1913/2035 (94%) fetuses. The mean nasal bone length increased linearly with gestation from 6.2 mm at 19 weeks to 6.8 mm at 22 weeks. Nasal bone hypoplasia, defined by absence of the bone or a measurement below the 2.5th centile, was observed in 34/1899 (1.8%) chromosomally normal fetuses (1.8%), in 5/5 fetuses with trisomy 21 and in 0/9 fetuses with other chromosomal defects. Conclusion At 19–22 weeks' gestation, nasal bone hypoplasia is observed in a high proportion of trisomy 21 fetuses and in less than 2% of chromosomally normal fetuses. Copyright © 2003 ISUOG. Published by John Wiley & Sons, Ltd.