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Isolated fetal ascites caused by Wolman disease
Author(s) -
BenHaroush A.,
Yogev Y.,
Levit O.,
Hod M.,
Kaplan B.
Publication year - 2003
Publication title -
ultrasound in obstetrics and gynecology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.202
H-Index - 141
eISSN - 1469-0705
pISSN - 0960-7692
DOI - 10.1002/uog.73
Subject(s) - medicine , ascites , fetus , disease , pregnancy , genetics , biology
Wolman disease is a rare autosomal‐recessive disorder caused by reduced levels of lysosomal acid lipase. It occurs in infancy and is fatal in most cases before the age of 1 year. Affected infants show signs of lipid storage in most tissues, including hepatosplenomegaly, abdominal distension, vomiting, steatorrhea, failure to thrive, and adrenal calcifications. We present a case of isolated fetal ascites diagnosed at 32 weeks of gestation, with negative work‐up for immune and non‐immune hydrops fetalis and congenital infections and malformations. After delivery, the diagnosis of Wolman disease was established. Although rare, storage diseases such as Wolman disease should be considered in cases of isolated fetal ascites. Copyright © 2003 ISUOG. Published by John Wiley & Sons, Ltd.