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Spectrum and outcome of prenatally diagnosed fetal tumors
Author(s) -
Kamil D.,
Tepelmann J.,
Berg C.,
Heep A.,
AxtFliedner R.,
Gembruch U.,
Geipel A.
Publication year - 2008
Publication title -
ultrasound in obstetrics and gynecology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.202
H-Index - 141
eISSN - 1469-0705
pISSN - 0960-7692
DOI - 10.1002/uog.5260
Subject(s) - medicine , teratoma , malignancy , fetus , sacrococcygeal teratoma , hemangioma , retrospective cohort study , prenatal diagnosis , histology , obstetrics , pregnancy , radiology , surgery , pathology , biology , genetics
Objective To describe the spectrum of prenatally diagnosed fetal tumors, and the course and fetal outcome in affected pregnancies. Methods This was a retrospective study in two German tertiary referral centers of 84 fetuses with tumors diagnosed in the prenatal period. The tumors were classified according to their location and histology. Results The most common site of origin was the heart (20/84, 23.8%), followed by the face and neck region (19/84, 22.6%) and the abdomen (16/84, 19%). Lymphangiomas (21/84, 25%) and rhabdomyomas (19/84, 22.6%) comprised half of the tumor histology. Less frequently, teratomas (14/84, 16.6%) and hemangiomas (12/84, 14.2%) were seen. Complications included arrhythmia in cases with rhabdomyoma (8/19, 42%) and signs of heart failure in cases with hemangioma (4/12, 33%) and teratoma (4/14, 28.6%). The overall survival rate was 75%. Cases with either a histological diagnosis of teratoma or tumor located in the brain had the worst prognosis. Conclusion The combination of sonographic features and their location allows reliable prediction of the histological type in the vast majority of fetal tumors. Malignancy, associated malformations and aneuploidy are observed infrequently. Knowledge of the presence of a fetal tumor facilitates close surveillance by a specialized team, which might lead to early recognition of problems and improve perinatal outcome. Copyright © 2008 ISUOG. Published by John Wiley & Sons, Ltd.