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Metopic suture in fetuses with trisomy 21 at 11 + 0 to 13 + 6 weeks of gestation
Author(s) -
Faro C.,
Wegrzyn P.,
Benoit B.,
Chaoui R.,
Nicolaides K. H.
Publication year - 2006
Publication title -
ultrasound in obstetrics and gynecology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.202
H-Index - 141
eISSN - 1469-0705
pISSN - 0960-7692
DOI - 10.1002/uog.2653
Subject(s) - trisomy , fetus , medicine , gestation , frontal bone , fibrous joint , anatomy , nasal bone , skull , significant difference , pregnancy , biology , genetics
Objective To investigate the development of the frontal bones and metopic suture in fetuses with trisomy 21 at 11 + 0 to 13 + 6 weeks of gestation. Methods Three‐dimensional (3D) ultrasound was used to measure the height of and gap between the frontal bones in 75 fetuses with trisomy 21 and these were compared to the measurements in 200 normal fetuses at 11 + 0 to 13 + 6 (median, 12 + 6) weeks of gestation. Results In the fetuses with trisomy 21, compared to the normal fetuses, there was no significant difference in either the height of the frontal bones (mean difference 0.16 SD, range −1.78 to 2.17 SD; P = 0.369) or the gap between them (mean difference 0.012, 95% CI −0.073 to 0.097; P = 0.780). Additionally, within the group of trisomy 21 fetuses there were no significant differences in the development of the frontal bones and metopic suture between those with absent ( n = 46) and those with present ( n = 29) nasal bone. Conclusions In trisomy 21 the development of the frontal bones and metopic suture is as normal and is independent from the development of the nasal bones. Copyright © 2005 ISUOG. Published by John Wiley & Sons, Ltd.