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P07.14: Dynamic assays of inhibin B, anti‐Mullerian hormone and estradiol following FSH stimulation and ovarian ultrasonography as predictors of IVF outcome
Author(s) -
Rabinowitz R.,
Markowitz M. E.,
Margalioth M. E. J.,
Shen S. O.,
BenChetrit B. A.,
Mimoni M. T.,
Gal G. M.,
Spitz S. I. M.,
ZylberHaran Z. H. E.,
Brooks B. B.,
EldarGeva E. G. T.
Publication year - 2005
Publication title -
ultrasound in obstetrics and gynecology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.202
H-Index - 141
eISSN - 1469-0705
pISSN - 0960-7692
DOI - 10.1002/uog.2421
Subject(s) - anti müllerian hormone , antral follicle , luteal phase , follicular phase , medicine , endocrinology , ovarian reserve , andrology , hormone , embryo transfer , basal (medicine) , pregnancy , biology , infertility , insulin , genetics
BACKGROUNDWe evaluated basal and dynamic hormonal markers [(FSH, inhibin B, estradiol and anti-Mullerian hormone (AMH)] during the follicular phase and luteal phase of the menstrual cycle and ultrasonic ovarian morphology as predictors of IVF outcome.METHODSFifty-six women, aged <38 years, with normal day 3 FSH levels were included prospectively. Serum estradiol, inhibin B and AMH were measured before and 24 h after administration of 300 IU of recombinant FSH on cycle day 3-4 and during the luteal phase. Ovarian volume and antral follicle count (AFC) were evaluated on cycle day 3-4. The predictive value of oocyte number and pregnancy were assessed using uni- and multivariate analysis.RESULTSPoor responders (<6 oocytes) had significantly lower luteal AMH levels, while high responders (>20 oocytes) had significantly higher AFC, AMH and luteal stimulated inhibin B and estradiol than normal responders. Multivariate regression analyses showed that the best models for predicting oocyte number included AFC, follicular phase AMH and stimulated inhibin B. Only AMH showed a significant difference between pregnant and non-pregnant women at both cycle phases.CONCLUSIONSIn young women (<38 years), AFC or basal AMH and stimulated inhibin B predict ovarian response for IVF. The only predictor for pregnancy is follicular or luteal phase AMH.