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Maternal and perinatal outcomes of pregnant women with SARS‐CoV ‐2 infection
Author(s) -
Gabriele Saccone,
Cihat Şen,
Daniele Di Mascio,
Alberto Galindo,
Amos Grünebaum,
Jun Yoshimatsu,
Milan Stanojević,
Asım Kurjak,
Frank A. Chervenak,
María José Rodríguez Suárez,
Zita Maria GambacortiPasserini,
Maria Baz,
Esther Vanessa Aguilar Galán,
Yolanda Cuñarro López,
J.A de León Luis,
Ignacio Cueto Hernández,
Ignacio Herraı̀z,
Cecilia Villalaín,
Roberta Venturella,
Giuseppe Rizzo,
Ilenia Mappa,
Giovanni Gerosolima,
L Hellmeyer,
J. Königbauer,
Giada Ameli,
T. Frusca,
Nicola Volpe,
Giovanni Battista Luca Schera,
Stefania Fieni,
Eutalia Esposito,
Giuliana Simonazzi,
G. Di Donna,
A. Youssef,
Anunzia Della Gatta,
Mariano Catello Di Donna,
Vito Chiàntera,
Natalina Buono,
Giulio Sozzi,
Pantaleo Greco,
Danila Morano,
Beatrice Bianchi,
Maria Giulia Marino,
Federica Laraud,
Arianna Ramone,
Angelo Cagnacci,
Fabio Barra,
Claudio Gustavino,
Simone Ferrero,
Fabio Ghezzi,
Antonella Cromi,
Antonio Simone Laganá,
Valentina Laurita Longo,
Francesca Stollagli,
Angelo Sirico,
Antonio Lanzone,
Lorenza Driul,
Fabiana Cecchini,
Serena Xodo,
Brian Arturo Mondeja Rodríguez,
Felipe MercadoOlivares,
Deena Elkafrawi,
Giovanni Sisti,
Rosanna Esposito,
Antonio Coviello,
Marco Cerbone,
Maddalena Morlando,
Antonio Schiattarella,
Nicola Colacurci,
Pasquale De Franciscis,
I. Cataneo,
Marinella Lenzi,
Fabrizio Sandri,
Riccardo Buscemi,
Giorgia Gattei,
Francesca Della Sala,
Eleonora Valori,
Maria Cristina Rovellotti,
Elisa Doné,
Gilles Faron,
Léonardo Gucciardo,
Valentina Esposito,
Flaminia Vena,
Antonella Giancotti,
Roberto Brunelli,
Ludovico Muzii,
Luigi Nappi,
Felice Sorrentino,
Marco Liberati,
Danilo Buca,
Martina Leombroni,
F. Di Sebastiano,
Massimo Piergiuseppe Franchi,
Quintino Cesare Ianniciello,
Simone Garzon,
Giuliano Petriglia,
Leonardo Borrello,
Albaro Josè NietoCalvache,
Juan Manuel BurgosLuna,
Caroline Kadji,
Andrew Carlin,
Elisa Bevilacqua,
Marina Moucho,
Pedro Viana Pinto,
Rita Figueiredo,
José Morales Roselló,
Gabriela Loscalzo,
Alicia Martínez-Varea,
Vincente Diago,
Jesús S. Jiménez López,
Alicia Yeliz Aykanat,
Stefano Cosma,
Andrea Carosso,
Chiara Benedetto,
Amanda Bermejo,
Otto Henrique May Feuerschuette,
Özlem Uyanıklar,
Sakine Rahimli Ocakouglu,
Zeliha Atak,
Reyhan Gündüz,
Esra Tuştaş Haberal,
Bernd Froessler,
Anupam Parange,
Peter Palm,
Igor Samardjiski,
Chiara Taccaliti,
Erhan Okuyan,
G. Daskalakis,
Rodrigo De,
Alejandro Pittaro,
María Luisa González-Durán,
Ana Concheiro Guisán,
Şerife Özlem Genç,
B Zlatohlávková,
Anna Luengo Piqueras,
Dolores Esteban Oliva,
Aylin Pelin Çil,
Oluş Api,
Panos J. Antsaklis,
Liana Pleș,
Ioannis Kyvernitakis,
Holger Maul,
Marcel Malan,
Albert Lila,
Roberta Granese,
Alfredo Ercoli,
Giuseppe Zoccali,
Andrea Villasco,
Nicoletta Biglia,
Mădălina Irina Ciuhodaru,
Elena Costa,
Caroline Daelemans,
Axelle Pintiaux,
Elif Gül Yapar Eyı,
Elisa Cueto,
Eran Hadar,
Sarah Dollinger,
Noa A Brzezinski-Sinai,
Erasmo Huertas,
Pedro Arango,
Amadeo Sanchez,
Javier Alfonso Schvartzman,
Liviu Cojocaru,
Şifa Turan,
Özhan Turan,
Maria Carmela Di Dedda,
Rebeca Garrote Molpeceres,
Snezana Zdjelar,
Tanja Premru-Sršen,
Lilijana KornhauserCerar,
Mirjam Druškovič,
V. De Robertis,
Vedran Stefanović,
Irmeli Nupponen,
Kaisa Nelskylä,
Zulfiya Khodjaeva,
Ksenia A. Gorina,
Г. Т. Сухих,
Giuseppe Maria Maruotti,
Silvia Visentin,
Erich Cosmi,
Jacopo Ferrari,
Alessandra Gatti,
Daniela Luvero,
Roberto Angioli,
Ludovica Puri,
Marco Palumbo,
Giusella D'Urso,
Francesco Colaleo,
Agnese Maria Chiara Rapisarda,
Ilma Floriana Carbone,
Lamberto Manzoli,
Maria Elena Flacco,
G. Nazzaro,
Mariavittoria Locci,
Maurizio Guida,
Attilio Di Spiezio Sardo,
Pierluigi Benedetti Panici,
Asma Khalil,
Vincenzo Berghella,
Giuseppe Bifulco,
Giovanni Scambia,
Fulvio Zullo,
F. D’Antonio
Publication year - 2021
Publication title -
ultrasound in obstetrics and gynecology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.202
H-Index - 141
eISSN - 1469-0705
pISSN - 0960-7692
DOI - 10.1002/uog.23107
Subject(s) - medicine , pregnancy , obstetrics , miscarriage , mechanical ventilation , neonatal intensive care unit , gestation , cohort study , retrospective cohort study , pediatrics , genetics , biology
Objectives To evaluate the maternal and perinatal outcomes of pregnancies affected by SARS‐CoV‐2 infection. Methods This was a multinational retrospective cohort study including women with a singleton pregnancy and laboratory‐confirmed SARS‐CoV‐2 infection, conducted in 72 centers in 22 different countries in Europe, the USA, South America, Asia and Australia, between 1 February 2020 and 30 April 2020. Confirmed SARS‐CoV‐2 infection was defined as a positive result on real‐time reverse‐transcription polymerase chain reaction (RT‐PCR) assay of nasopharyngeal swab specimens. The primary outcome was a composite measure of maternal mortality and morbidity, including admission to the intensive care unit (ICU), use of mechanical ventilation and death. Results In total, 388 women with a singleton pregnancy tested positive for SARS‐CoV‐2 on RT‐PCR of a nasopharyngeal swab and were included in the study. Composite adverse maternal outcome was observed in 47/388 (12.1%) women; 43 (11.1%) women were admitted to the ICU, 36 (9.3%) required mechanical ventilation and three (0.8%) died. Of the 388 women included in the study, 122 (31.4%) were still pregnant at the time of data analysis. Among the other 266 women, six (19.4% of the 31 women with first‐trimester infection) had miscarriage, three (1.1%) had termination of pregnancy, six (2.3%) had stillbirth and 251 (94.4%) delivered a liveborn infant. The rate of preterm birth before 37 weeks' gestation was 26.3% (70/266). Of the 251 liveborn infants, 69/251 (27.5%) were admitted to the neonatal ICU, and there were five (2.0%) neonatal deaths. The overall rate of perinatal death was 4.1% (11/266). Only one (1/251, 0.4%) infant, born to a mother who tested positive during the third trimester, was found to be positive for SARS‐CoV‐2 on RT‐PCR. Conclusions SARS‐CoV‐2 infection in pregnant women is associated with a 0.8% rate of maternal mortality, but an 11.1% rate of admission to the ICU. The risk of vertical transmission seems to be negligible. © 2020 International Society of Ultrasound in Obstetrics and Gynecology