EP19.02: Increased uterine artery diameter protects from altitude associated reduction in fetal growth

Conclusion Second trimester UtA diameter in multigenerational HA pregnant resident is more than pregnant women at LA and it contributes to protection of fetal growth • Two linked prospective cohort studies in India • Couples with > 3 antecedent HA generation from SNM Hospital Leh (about 3,500m above sea level),and couple residing in low altitude , from AIIMS, New Delhi, were recruited • Healthy women with singleton pregnancy not affected by chromosomal or structural anomaly , dated by CRL in first trimester • Ultrasound for fetal growth and uterine artery dopplers was done in each trimester. • Uterine artery diameter was measured between 18-23 weeks gestation (Voluson E8, GE), three times before, at and after crossover of external iliac artery on both sides and values averaged . All measurements were taken by same operator at each site. • Fetal growth restriction was defined as birthweight < 5th centile using WHO charts Methodology