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EP14.10: The effect of hydroxychloroquine therapy on pregnancy outcomes and fetal heart in mothers with positive anti‐SSA or anti‐SSB antibodies
Author(s) -
Zhao Y.
Publication year - 2019
Publication title -
ultrasound in obstetrics and gynecology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.202
H-Index - 141
eISSN - 1469-0705
pISSN - 0960-7692
DOI - 10.1002/uog.21379
Subject(s) - medicine , fetus , pregnancy , endocardial fibroelastosis , gestation , hydroxychloroquine , fetal echocardiography , heart block , obstetrics , heart disease , atrioventricular block , gestational age , antibody , disease , prenatal diagnosis , immunology , electrocardiography , genetics , covid-19 , infectious disease (medical specialty) , biology
Methods Mothers with positive anti-SSA or anti-SSB antibodies were selected from Jan 2016 to Nov 2018. They were divided into two groups according with (Group A) or without (Group B) Hydroxychloroquine therapy during gestation. Cases in group A (n=91) were screened fetal echocardiography from gestational weeks 1628. Cases in group B (n=19) were diagnosed because fetal CHB or endocardial fibroelastosis (EFE) as the first manifestations in fetal echocardiography. All cases were performed fetal echocardiography in detail, the types and levels of maternal antibodies, Conclusion Maternal anti-SSA or anti-SSB antibodies can associate with poor pregnancy outcomes. The fetal cardiac events are lighter with Hydroxychloroquine therapy and have good prognosis than non-therapy. Figure. EFE at LA, atrial septum and RA with materal anti-SSA antibody (+++) and anti-SSB antibody (+++) Results