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EP08.26: Outcome of the first two confirmed cases of congenital Zika virus
Author(s) -
Melo A.O.,
Tavares J.S.,
Malinger G.,
Oliveira P.S.,
Ximenes R.,
Matias M.A.,
Gama G.L.,
Regis T.D.,
Amorim M.M.
Publication year - 2019
Publication title -
ultrasound in obstetrics and gynecology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.202
H-Index - 141
eISSN - 1469-0705
pISSN - 0960-7692
DOI - 10.1002/uog.21278
Subject(s) - medicine , ventriculomegaly , microcephaly , zika virus , hypoplasia , cerebellar vermis , polymicrogyria , corpus callosum , cerebellar hypoplasia (non human) , arthrogryposis , pediatrics , pathology , pregnancy , cerebellum , surgery , magnetic resonance imaging , radiology , fetus , virus , virology , genetics , biology
Congenital Zika Syndrome confirmed by RT-PCR. The cases were followed from the gestation through serial ultrasound (GE E8). Amniocentesis was performed at week 28 and Magnetic Resonance at week 29. Postpartum outcomes were also monitored. Case 1 – A physical therapist, 33 years old, exanthema with seven weeks of pregnancy. Neuroimaging findings: microcephaly, lysencephaly, subcortical calcifications, cerebellar vermis and corpus callosum hypoplasia, increased interhemispheric space, and reduced brain volume. Zika virus was detected by RT-PCR in amniotic fluid. Newborn female, cephalic perimeter of 30.5 cm, Apgar at 1st and 5th’ of 9 and 10. The child received therapy at the Professor Joaquim Amorim Neto Research Institute until the present. The Gross Motor Function Measure was applied with 16(median of 116), 23(median of 170) and 34(median of 206) weeks of life, level II by GMFCS, without seizures, walking and attending to school. Case 2 – A 23 years old presented rash with 18 weeks. Neuroimaging findings: severe and asymmetric ventriculomegaly, lysencephaly, absence of thalamus, severe cerebellar and cerebellar vermis hypoplasia, unilateral microphthalmia, cataract and arthrogryposis. Newborn male, cephalic perimeter of 36.5 cm and Apgar 3/3. He died at 10 hours of life. The presence of Zika virus had already been detected in the amniotic fluid by RT-PCR and the presence of viral material was confirmed after necropsy in brain tissue, meninges and kidney. EP08.26 Outcome of the first two confirmed cases of Congenital Zika virus Adriana Suely De O. Melo1, 2, Jousilene S. Tavares1, Gustavo Malinger3, Patricia S. Oliveira4, Renato Ximenes5, Maria Conceiçao A. Matias1, Gabriela L. Gama1, Thamyris D. Regis1, Melania M. Amorim1, 2 1.Instituto de Pesquisa Professor Joaquim Amorim Neto, Campina Grande, Brazil. 2. UNIFACISA, Campina Grande, Brazil. 3. OB-GYN Ultrasound Unit, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel. 4. DDI Federal University of Sao Paulo UNIFESP, Sao Paulo, Brazil. 5. DDI Federal University of São Paulo UNIFESP, Campinas, Brazil