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EP07.19: First trimester diagnosis of open neural tube defect: case series at a primary referral centre
Author(s) -
S.R. Satarkar
Publication year - 2019
Publication title -
ultrasound in obstetrics and gynecology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.202
H-Index - 141
eISSN - 1469-0705
pISSN - 0960-7692
DOI - 10.1002/uog.21245
Subject(s) - medicine , neural tube , referral , series (stratigraphy) , first trimester , pediatrics , obstetrics , pregnancy , family medicine , gestation , embryo , paleontology , genetics , biology , microbiology and biotechnology
Spina bifida type of open neural tube defect results from failure of closure of distal neuropore during embryogenesis. First trimester diagnosis in challenging. Material and Method 720 patients were referred for Nuchal translucency (NT) scan between Jan2018 to March 2019. The mid-sagittal plane was studied in detail . After measuring NT, we also evaluated the 3 echogenic lines in posterior fossa. We measured intracranial translucency ( IT). Spine was evaluated in sagittal and coronal sections,the brainstem (BS) and brainstem occipital bone (BSOB) ratio was calculated in suspected cases. Findings We diagnosed 3 cases of open spina bifida. In these cases, the normal 3 echogenic line pattern of posterior fossa was not seen. IT could not be measured.BS:BSOB ratio was >1. Kyphosis and deficient skin seen in 2 patients, meningocele seen in 1 patient. Conclusion Evaluation of the posterior fossa, measuring IT and scanning the spine in sagittal and coronal sections is extremely useful for diagnosing spina bifida in first trimester. Figure 1. Deformed spine Figure 2. Absent IT