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EP06.15: Tuberous sclerosis complex: the role of ultrasonography in the detection of different brain manifestations
Author(s) -
Farajov A.T.,
Mammadova G.,
Garayeva G.,
Azimova A.,
Huseynov E.
Publication year - 2019
Publication title -
ultrasound in obstetrics and gynecology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.202
H-Index - 141
eISSN - 1469-0705
pISSN - 0960-7692
DOI - 10.1002/uog.21215
Subject(s) - tuberous sclerosis , subependymal zone , subependymal giant cell astrocytoma , medicine , pathology , lesion , astrocytoma , tsc1 , giant cell , radiology , glioma , biology , cancer research , apoptosis , biochemistry , pi3k/akt/mtor pathway
•Tuberous sclerosis complex (TSC) is a multisystemic autosomal dominant disorder caused by TSC1 orTSC2 mutation that manifests with the growth of benign hamartomas in various organ systems.The Gene products hamartin (TSC1) and tuberin (TSC2) which are tumor suppressors,have significant importance in regulation of cell growth and proliferation. Multiple cardiac rhabdomyomas, serebral lesions as well as subependymal nodules, subcortical tubersand Subependymal giant cell astrocytoma are the main ultrasound findings of TSC during the fetal period. •Two cases below show the role of ultrasonography in detection of different cerebral manifestation of TSC.The diagnosis of definitive TSC in both cases were based on two major criteria and both of the cases were sporadic.