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EP04.20: Increased rates of pregnancy complications after positive screening results
Author(s) -
Yarygina T.A.,
Bataeva R.S.
Publication year - 2019
Publication title -
ultrasound in obstetrics and gynecology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.202
H-Index - 141
eISSN - 1469-0705
pISSN - 0960-7692
DOI - 10.1002/uog.21175
Subject(s) - medicine , ductus venosus , obstetrics , fetus , population , miscarriage , pregnancy , prospective cohort study , gynecology , genetics , biology , environmental health
Methods. This was a prospective study on screening for FA and pSGA in 3504 singleton pregnancies by an algorithm that combines maternal factors, mean arterial pressure, maternal serum biochemistry (free b-hCG and PAPP-A), ultrasound markers (nuchal translucency thickness, tricuspid valve and ductus venosus flow, nasal bone), and uterine artery pulsatility index at 11-13 weeks' gestation at Fetal Medicine Center (Russia). We excluded 1428 cases because of loss to follow-up (n = 1269) and fetal chromosomal and strucrural abnormalities (n=159). With the proposed cut-offs of ≤1:100 for trisomies, and ≤1:150 for pSGA the study population of 2076 was divided into: Group 1: False-positive (FP) for fetal aneuploidy (n=55), including cases with low (n=23) and high (n=32) risk for pSGA; Group 2: low-risk for FA and pSGA (n=1563).