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P20.01: Bovine aortic arch variant T2BAA: association with cardiovascular pathologies and fetal structural abnormalities
Author(s) -
Pinto A.,
Prisco L.,
Stella N.,
Luise C.,
Menditto A.
Publication year - 2019
Publication title -
ultrasound in obstetrics and gynecology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.202
H-Index - 141
eISSN - 1469-0705
pISSN - 0960-7692
DOI - 10.1002/uog.21072
Subject(s) - medicine , aortic arch , fetus , cardiology , great arteries , population , ventricle , aorta , fetal echocardiography , common carotid artery , anatomy , prenatal diagnosis , pregnancy , carotid arteries , biology , genetics , environmental health
Objectives: The aim of this pilot study was to determine whether first trimester saliva progesterone (SPr) is altered during the first trimester of pregnancy and its role as a screening test for spontaneous preterm delivery (sPTD). Methods: Saliva progesterone together with maternal characteristics and biophysical markers (cervical length and uterine artery Doppler) were assessed at 11-14 weeks’ gestation in a nested case-control study which included 30 women who later developed sPTD and 57 matched controls delivering at term. Saliva samples were centrifuged, and the supernatants were frozen at -80oC until samples were analysed. The distribution of measured SPr and biophysical markers in the term and sPTD groups were compared. Logistic regression analysis was used to evaluate if any variable was significantly associated with sPTD. Results: The mean value of SPr in the first trimester of pregnancy was significantly lower in women who delivered prematurely compared to controls (426.3 ± 24.7 pg/mL vs 512.3 ± 26.3 pg/mL, p = 0.037), being also lesser in those women who delivered bellow 34 weeks (387.0 ± 41.0 pg/mL vs 511.8 ± 25.8 pg/mL, p = 0.050). Neither cervical length nor uterine artery Doppler were associated with sPTD. Logistic regression analysis demonstrated that a combination of maternal characteristics and SPr provided a significant contribution in the prediction of sPTD before 34 and 37 weeks, being the detection rate, at a fixed 10% false positive rate, at around 45% and 20%, respectively. Conclusions: This pilot study concluded that saliva progesterone level is reduced during the first trimester of pregnancy in women who later delivered prematurely, and it might be particularly useful in predicting preterm delivery before 34 weeks of gestation.