Premium
EP15.19: Assessing myometrial infiltration by measuring the tumour‐free distance and depth of invasion through 2D transvaginal ultrasound among patients with endometrial cancer
Author(s) -
Navarete H.C.,
DavidBustamante L.
Publication year - 2018
Publication title -
ultrasound in obstetrics and gynecology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.202
H-Index - 141
eISSN - 1469-0705
pISSN - 0960-7692
DOI - 10.1002/uog.20014
Subject(s) - medicine , infiltration (hvac) , endometrial cancer , ultrasound , histopathology , transvaginal ultrasound , diagnostic accuracy , radiology , cancer , pathology , physics , thermodynamics
Endometrial cancer is the fifth most common malignancy affecting women. Transvaginal ultrasound (TVS) has been shown to have comparable accuracy with MRI in determining myometrial invasion, which is one of the most important prognostic factors in the preoperative evaluation of patients with endometrial cancer. Main Objective: To determine the diagnostic accuracy of 2D TVS in assessing myometrial infiltration by measuring the tumor free distance (TFD) and depth of invasion (DOI) among patients with endometrial cancer admitted for elective surgery at Philippine General Hospital Department of Obstetrics and Gynecology. Materials and Methods: This prospective validation study involved 49 patients with endometrial cancer admitted for elective surgery at the Philippine General Hospital from October 1, 2016 to February 28, 2017. All patients had 2D TVS at least within 1 week prior to surgery. The TFD and the DOI were measured and compared with the histopathologic result. Diagnostic accuracy in assessing myometrial infiltration were computed and test of association was done using 2x2 Fischer Exact test at 0.05α while AUC-ROC was plotted. Conclusion: Assessment of myometrial infiltration by measuring the TFD and DOI through 2D TVS among patients with endometrial cancer demonstrated clinically acceptable accuracy with higher sensitivity in detecting >50% myometrial infiltration. TFD (cut off value of ≤0.82cm) has a higher accuracy compared with DOI in predicting >50% myometrial infiltration. Figure 1. Measurement of DOI & TFD