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EP09.01: Antenatal diagnosis of absence of septum pellucidum
Author(s) -
Ben MBarek I.,
Tassin M.,
Guet A.,
Simon I.,
Mairovitz V.,
Mandelbrot l.,
Picone O.
Publication year - 2018
Publication title -
ultrasound in obstetrics and gynecology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.202
H-Index - 141
eISSN - 1469-0705
pISSN - 0960-7692
DOI - 10.1002/uog.19908
Subject(s) - medicine , polymicrogyria , amniocentesis , septum pellucidum , dysplasia , prenatal diagnosis , agenesis , pregnancy , fetus , cortical dysplasia , obstetrics , pediatrics , radiology , pathology , surgery , magnetic resonance imaging , genetics , biology
Conclusion ASP can be diagnosed during routine 2nd trimester morphological ultrasound screening. The prenatal work-up should include an amniocentesis for karyotyping and CGH array. Fetal cerebral MRI is mandatory. The antenatal diagnosis is reassuring when the ASP is isolated, but still carries a 20% risk of SOD which may be diagnosed postnatally. This should be mentioned during prenatal counselling Table 1: Summary of the cohort. CGH, array, comparative genomic hybridization Array ; ASP, absence of septum pellucidum; CC, corpus collosum; GH, growth hormon ; MRI, magnetic resonance imaging; TSH, thyroid stimulating hormon ; SUA, Single Umbilical Artery ; WG, Week of gestation
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