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OP03.02: A score system to assess the risk of ovarian malignancy at ultrasound: predictors and nomogram‐based analyses
Author(s) -
Chiappa V.,
Bogani G.,
Montanelli L.,
Franchi D.,
Tartamella J.,
Verri D.,
Raspagliesi F.,
Fruscio R.
Publication year - 2018
Publication title -
ultrasound in obstetrics and gynecology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.202
H-Index - 141
eISSN - 1469-0705
pISSN - 0960-7692
DOI - 10.1002/uog.19411
Subject(s) - medicine , malignancy , nomogram , multivariate analysis , univariate analysis , breast cancer , cyst , ultrasound , gynecology , cancer , radiology
Methods: Data of women with adnexal masses were prospectively collected in US specialized centres of three gynecologic oncology units. We retrospectively evaluated how anamnestic, clinical and US characteristics impact on the ROM detected at surgery. Predictors of malignancy were identified using uniand multivariate analyses. A nomogram assessing the ROM was build. Results: Overall,1053 patients were included. Mean (SD) age was 51.7 (15.2) years. Malignancy was detected in 458(43%) cases. Univariate analysis showed that age, menopausal status, familiar history of breast cancer, morphological class of the cyst, cysts’diameter, cysts’content, color score, presence of solid areas, Ca125 levels, bilateral cysts, crescent sign visibile, acoustic shadows correlated with the presence of malignancy at final histology. At multivariate analysis significative variables were: Ca125 levels (OR: 1.01 (95%CI: 1.00, 1.02)per 10-unit increase;p=0.009), bilateral cysts (OR: 2.13 (95%CI:1.23, 3.77); p=0.007), cysts’ diameter (OR: 1.06 (95%: 1.02, 1.10) per 1 cm increase;p=<0.001), cysts’content (OR: 0.83 (95%CI: 0.74, 0.92); p=0.001), solid area (OR: 7.14 (95%CI: 3.81, 13.3); p<0.001) and color score (OR: 4.34 (3.37, 5.64); p=0.001). Additionally, family history positive for breast cancer was associated with an increased ROM (OR: 1.59 (95%CI: 0.92, 2.73); p=0.093). A nomogram was created to assess the risk on the basis of various patients’ and US characteristics (C-index: 0.77).