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EP14.25: Placental weight and volume related to birthweight and third trimester maternal blood sample in normal and IUGR pregnancies
Author(s) -
Jakó M.,
Suranyi A.,
Kaizer L.,
Bártfai G.,
Németh G.
Publication year - 2017
Publication title -
ultrasound in obstetrics and gynecology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.202
H-Index - 141
eISSN - 1469-0705
pISSN - 0960-7692
DOI - 10.1002/uog.18541
Subject(s) - medicine , birth weight , obstetrics , hematocrit , gestational age , placenta , fetus , percentile , pregnancy , mean platelet volume , andrology , platelet , biology , genetics , statistics , mathematics
Objectives: To investigate human long bone development in fetuses with intrauterine growth restriction (IUGR) by analysing distal femoral epimetaphyseal structures and bone morphometrics on prenatal MR imaging. Methods: This retrospective study included 14 fetuses (mean gestational age, 26 weeks 2 days; range, 21 weeks 3 days to 33 weeks) with IUGR caused by placental insufficiency, without other brain or body abnormalities, as well as a total of 192 age-matched normal fetuses. On 1.5-T echo-planar MR images, diaphyseal and epiphyseal morphometric measurements were assessed, and, using a grading system, the cartilaginous epiphyseal and metaphyseal shape, secondary ossification, and the perichondrium were qualitatively analysed. Student’s t-testing was used to compare the morphometric measurements of IUGR fetuses with normal fetuses, and descriptive statistics were used to compare the qualitative bone characteristics. Results: The morphometric measurements of the IUGR fetuses did not exceed the minimum normative measurements at any gestational age (diaphyseal length: p <0.0001 0.0053; epiphyseal length: p <0.0001 0.0022; epiphyseal width: p <0.0001 0.0032). Overall, the same grading for cartilaginous epiphyseal shape as observed in IUGR fetuses was found in 28.6% 100% of normal fetuses, for the metaphyseal shape in 7.1% 94.4%, for secondary ossification in 16.7% 100%, and for the perichondrium in 12.5%91.7%. Conclusions: On prenatal MR imaging, fetuses with placental-based IUGR exhibit long bone shortening, whereas their qualitative bone characteristics appear within normal limits. Consequently, the presence of qualitative bone abnormalities should include the differential diagnosis of various fetal skeletal disorders.