OP21.04: The impact of pre‐eclampsia for mothers and infants: analysis of outcomes from the PREDICT study

Methods: The data of diabetic women using insulin who were followed in our departments were reviewed retrospectively. The relationships between MCA-PSV and umbilical cord pO2, pCO2, base deficit, hemoglobin, and birth weight were analysed. Results: A total of 120 cases were included in the final analysis. The mean gestational age at Doppler evaluation was 37 weeks 3 days (Q1Q3: 37 weeks38 weeks 2 days), and the mean gestational age at delivery was 38 weeks 4 days± 3days. The mean HbA1c level and insulin dose were 5.7±1.0, and 25(1048), respectively. There was no statistically significant correlation between MCAPSV and pH, PO2, PCO2, base deficit, hemoglobin, and birth weight (-0. 0.043[0.64], -0.07[0.46], -0.110 [0.22], 0.083[0.37], 0.048 [0.60], 0.078 [0.4], respectively). At binary logistic regression analysis, no independent factor for the prediction of fetal acidosis (venous pH>7.23), and metabolic acidosis (base deficit >6.3mmol/L) was detected. Conclusions: MCAPSV is not a good indicator of fetal polycythemia or chronic hypoxia in fetuses of diabetic mothers. We propose that fetal well-being should be monitored with other tools in these circumstances.