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Assessment of variability of renal blood flow Doppler parameters during the menstrual cycle in women
Author(s) -
Krejza J.,
Ustymowicz A.,
Szylak A.,
Tomaszewski M.,
Hryniewicz A.,
Jawad A.
Publication year - 2005
Publication title -
ultrasound in obstetrics and gynecology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.202
H-Index - 141
eISSN - 1469-0705
pISSN - 0960-7692
DOI - 10.1002/uog.1771
Subject(s) - medicine , menstrual cycle , hematocrit , diastole , repeatability , coefficient of variation , hemodynamics , cardiology , blood pressure , blood flow , luteal phase , endocrinology , follicular phase , hormone , mathematics , statistics
Objective To estimate variability of renal flow Doppler parameters during the menstrual cycle in young women, and to explore whether the parameters oscillate substantially throughout the cycle. Methods The peak systolic, mean, and end‐diastolic velocities, pulsatility (PI) and resistance (RI) indices, acceleration time (AT) and index (AI) of the right renal artery were measured nine times during the cycle with duplex sonography in 14 healthy women (age range, 23–25 years), and correlated with plasma concentrations of 17β‐estradiol and progesterone. Coefficient of variation (CV), interclass correlation (ρ), and repeatability coefficients (RC) were used to measure the variability. Results The measures of the variability for AI and AT were: CV = 45.4% and 37.3%; ρ = 0.25 and 0.15; RC = 10.1 and 99.5, respectively. The CV for flow velocities varied from 24.1% to 25.5%, ρ from 0.49 to 0.50, RC from 22.7 for end‐diastolic to 63.3 for peak systolic velocity. The respective figures for PI and RI were: CV = 17% and 8.3%; ρ = 0.21 and 0.29; RC = 0.53 and 0.15. Fluctuations of the flow parameters, hematocrit, hemoglobin, heart rate, and systolic blood pressure during the menstrual cycle were insignificant, while the diastolic blood pressure decreased by about 7 mmHg ( P < 0.01) in the luteal phase. Conclusion The variability of renal flow Doppler parameters during the menstrual cycle in young healthy women is substantial. However, fluctuations of the values of the parameters throughout the cycle were non‐significant. Copyright © 2004 ISUOG. Published by John Wiley & Sons, Ltd.