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Effect of a nitric oxide donor on maternal hemodynamics in fetal growth restriction
Author(s) -
Tiralongo G. M.,
Pisani I.,
Vasapollo B.,
Khalil A.,
Thilaganathan B.,
Valensise H.
Publication year - 2018
Publication title -
ultrasound in obstetrics and gynecology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.202
H-Index - 141
eISSN - 1469-0705
pISSN - 0960-7692
DOI - 10.1002/uog.17454
Subject(s) - medicine , hemodynamics , nitric oxide , fetal growth , stroke volume , cardiac output , vascular resistance , cardiology , fetus , pregnancy , obstetrics , anesthesia , blood pressure , heart rate , biology , genetics
Objective To evaluate the effect on maternal cardiovascular parameters of treatment with a nitric oxide (NO) donor and plasma volume expansion in pregnancies complicated by fetal growth restriction (FGR). Methods Twenty‐six pregnant women with a diagnosis of FGR were treated with transdermal patches of a NO donor and plasma volume expansion by co‐administration of oral fluids. We compared the treated group to a historical control group of untreated FGR patients. Hemodynamic indices were obtained using the UltraSonic Cardiac Output Monitor system. Results At diagnosis, the two groups were similar in terms of maternal and hemodynamic characteristics. In the treated group, we found a significant increase in maternal cardiac output and stroke volume and a decrease in systemic vascular resistance after 2 weeks of therapy. No significant differences were found 2 weeks after diagnosis in the untreated group. The treated group delivered infants with higher birth‐weight centile than did the untreated control group. Conclusions The combined therapeutic approach of NO donor administration and plasma volume expansion in FGR apparently improves significantly maternal hemodynamic indices. Copyright © 2017 ISUOG. Published by John Wiley & Sons Ltd.