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Maternal cardiac function after HELLP syndrome: an echocardiography study
Author(s) -
Orabona R.,
Vizzardi E.,
Sciatti E.,
Prefumo F.,
Bonadei I.,
Valcamonico A.,
Metra M.,
Frusca T.
Publication year - 2017
Publication title -
ultrasound in obstetrics and gynecology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.202
H-Index - 141
eISSN - 1469-0705
pISSN - 0960-7692
DOI - 10.1002/uog.17358
Subject(s) - hellp syndrome , medicine , cardiology , ejection fraction , asymptomatic , hemodynamics , pregnancy , eclampsia , heart failure , genetics , biology
ABSTRACT Objective To evaluate maternal hemodynamics in asymptomatic women with a previous pregnancy affected by hemolysis, elevated liver enzymes and low platelets (HELLP) syndrome and compare the findings to those of women with previous pre‐eclampsia (PE) and controls with a previous uncomplicated pregnancy. Methods Women with a history of PE ( n = 60) or HELLP syndrome ( n = 49) and matched healthy controls ( n = 60) underwent echocardiography at 6 months to 4 years after delivery, recording left ventricular (LV) dimensions, ejection fraction (LVEF) and mass, right ventricular (RV) tricuspid annular plane systolic excursion and fractional area change (FAC). Diastolic filling (E/A and E/E′ ratios) and tissue Doppler imaging were evaluated for both ventricles and the myocardial performance index was calculated. Results Only women with previous HELLP syndrome showed significant LV concentric hypertrophy (20.4%). However, in both HELLP and PE groups, LV concentric remodeling (46.9% and 46.7%, respectively), diastolic dysfunction (expressed as altered E/A and E/E′ ratios) and reduced LVEF (14.3% and 21.7%, respectively) were documented. RV variables did not differ significantly between cases and controls, except for FAC and E/E′ ratio, which were slightly impaired in women with previous HELLP syndrome compared to those with previous PE (16.3% vs 10.0%, P = 0.04; 14.3% vs 3.3%, P = 0.03, respectively). Conclusions The significant overlap of echocardiographic features in women with previous PE and HELLP syndrome suggests that these two conditions share the same pathophysiology. However, HELLP syndrome may lead to more severe cardiovascular remodeling in the short to medium term after delivery. Copyright © 2016 ISUOG. Published by John Wiley & Sons Ltd.