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EP05.02: Doppler modifications in intrauterine growth restricted fetuses: the DOMINO study
Author(s) -
Marchi L.,
Elvan A.,
Scherjon S.,
Bilardo C.M.
Publication year - 2015
Publication title -
ultrasound in obstetrics and gynecology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.202
H-Index - 141
eISSN - 1469-0705
pISSN - 0960-7692
DOI - 10.1002/uog.15552
Subject(s) - medicine , percentile , fetus , gestational age , betamethasone , umbilical artery , doppler effect , middle cerebral artery , obstetrics , cardiology , pregnancy , genetics , physics , astronomy , biology , statistics , mathematics , ischemia
Methods At this moment 11 GR fetuses (AC ≤ 10th percentile and deflecting growth pattern) and 14 AGA fetuses (EFW ≥ 10th percentile, AC≥ 10th percentile, normal growth pattern and normal Doppler measurements) undergoing AS (betamethasone 12 mg i. m. 2 doses 24 hours apart) on medical indication were studied. Inclusion criteria were: singleton pregnancy, gestational age between 24 and 34 weeks, absence of chromosomal abnormalities, malformations or infections. Echocardiographic assessment of cardiac function including Myocardial Performance Index (MPI)left and right, E waveA wave ratio (E/A) left and right, Mitral and Tricuspid Annular Plane Systolic Excursion ( MAPSE and TAPSE) was performed. Conventional Dopplers (Umbilical artery -UA, middle cerebral artery-MCA, ductus venosusDV, uterine arteriesUtAA) were assessed as well. A ""baseline"" examination was performed before AS administration, followed by a second and third ultrasound at 24-48 hours and 7 days after the second dose, respectively.