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Evaluation of right ventricular function in fetal hypoplastic left heart syndrome by color tissue Doppler imaging
Author(s) -
Graupner O.,
Enzensberger C.,
Wieg L.,
Willruth A.,
Steinhard J.,
Gembruch U.,
Doelle A.,
Bahlmann F.,
Kawecki A.,
Degenhardt J.,
Wolter A.,
Herrmann J.,
AxtFliedner R.
Publication year - 2016
Publication title -
ultrasound in obstetrics and gynecology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.202
H-Index - 141
eISSN - 1469-0705
pISSN - 0960-7692
DOI - 10.1002/uog.14940
Subject(s) - hypoplastic left heart syndrome , medicine , isovolumic relaxation time , fetus , cardiology , gestation , doppler imaging , gestational age , fetal echocardiography , ventricular function , isovolumetric contraction , diastole , pregnancy , doppler echocardiography , heart disease , prenatal diagnosis , blood pressure , biology , genetics
Objective Postnatal outcome of fetuses with hypoplastic left heart syndrome ( HLHS ) is determined mainly by right ventricular function. Our study examines whether there are differences in right ventricular function during gestation of fetuses with HLHS compared with healthy fetuses. Methods A prospective study was conducted including 20 fetuses with HLHS and 20 gestational age‐matched controls. Peak systolic and diastolic right ventricular free wall velocities were assessed using color tissue Doppler imaging (c‐ TDI ). Subsequently, isovolumic time intervals, ejection time ( ET ′), E′/A′ ratio and tissue Doppler‐derived myocardial performance index ( MPI ′) were calculated. Possible changes to c‐ TDI indices during the course of pregnancy in both the HLHS group and the control group were investigated. Results Examination of right ventricular function revealed significantly lower E′ velocities (13.6 vs 21.0 cm/s; P = 0.017) and E′/A′ ratios (0.55 vs 0.76; P = 0.012) and prolonged isovolumic contraction time ( ICT ′) (57.0 vs 45.7 ms; P = 0.008) in the HLHS group compared with healthy fetuses. Furthermore, isovolumic relaxation time and MPI ′ increased significantly with gestational age in HLHS fetuses but not in controls. Values for systolic and diastolic peak velocities (E′, A′, S′), ET ′ and ICT ′ did not change significantly during gestation in either group. Conclusion Right ventricular function in HLHS is altered as early as in fetal life, well before palliative surgery is performed. Future research should provide further insight into ventricular remodeling during gestation in cases of HLHS . Copyright © 2015 ISUOG. Published by John Wiley & Sons Ltd.