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Longitudinal changes in maternal corin and mid‐regional proatrial natriuretic peptide in women at risk of pre‐eclampsia
Author(s) -
Khalil A.,
Maiz N.,
GarciaMandujano R.,
Elkhouli M.,
Nicolaides K. H.
Publication year - 2015
Publication title -
ultrasound in obstetrics and gynecology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.202
H-Index - 141
eISSN - 1469-0705
pISSN - 0960-7692
DOI - 10.1002/uog.14685
Subject(s) - medicine , atrial natriuretic peptide , gestation , natriuretic peptide , endocrinology , brain natriuretic peptide , pregnancy , gestational age , eclampsia , gestational hypertension , prospective cohort study , heart failure , genetics , biology
Objective Corin, an atrial natriuretic peptide‐converting enzyme, has been found to promote trophoblast invasion and spiral artery remodeling. Yet, elevated maternal plasma atrial natriuretic peptide ( ANP ) and corin levels have been reported in pregnancies complicated by pre‐eclampsia ( PE ). The aim of this study was to investigate longitudinal changes in maternal plasma levels of corin and mid‐regional proatrial natriuretic peptide ( MR‐PANP ) in pregnancies that develop PE and gestational hypertension ( GH ). Methods This was a nested case–control study drawn from a larger prospective longitudinal study in singleton pregnancies identified as being at high risk for PE by screening at 11 + 0 to 13 + 6 weeks' gestation. Blood samples were taken every 4 weeks until delivery. Values were compared in pregnancies that developed preterm PE (requiring delivery before 37 weeks' gestation), term PE , GH and those that remained normotensive. Results A total of 471 samples were analyzed from 122 women, including 85 that remained normotensive, 12 that developed GH , 13 term PE and 12 preterm PE . In the normotensive group, log 10 corin levels were associated with gestational age ( P < 0.01), whereas log 10 MR‐PANP levels were not. In the preterm‐ PE group, compared with the normotensive group, corin was significantly lower until 20 weeks' gestation ( P = 0.001). In the GH and term‐ PE groups, corin did not differ significantly from the normotensive group ( P = 0.637 and P = 0.161, respectively). Compared with the normotensive group, MR‐PANP levels were significantly higher in the pregnancies that developed preterm PE and GH ( P = 0.046 and P = 0.019, respectively), but not term PE ( P = 0.467). Conclusion Maternal‐plasma corin and MR‐PANP could potentially be useful biomarkers for the prediction of preterm PE . Copyright © 2014 ISUOG. Published by John Wiley & Sons Ltd.