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OC 15.03: Predicting symptomatic neonatal CMV infection in infected fetuses without brain anomalies at the time of prenatal diagnosis
Author(s) -
Stirnemann J.,
LeruezVille M.,
Sellier Y.,
Ville Y.
Publication year - 2014
Publication title -
ultrasound in obstetrics and gynecology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.202
H-Index - 141
eISSN - 1469-0705
pISSN - 0960-7692
DOI - 10.1002/uog.13558
Subject(s) - medicine , fetus , ventriculomegaly , prenatal diagnosis , gestational age , asymptomatic , oligohydramnios , pregnancy , amniocentesis , univariate analysis , obstetrics , amniotic fluid , viremia , multivariate analysis , immunology , genetics , virus , biology
Methods Retrospective analysis of 85 prenatally diagnosed cases of fetal CMV infection (2008 to 2013). Univariate and multivariate analysis at the time of prenatal diagnosis included gestational age at maternal primary infection and interval to prenatal diagnosis with US anomalies subdivided into severe brain anomalies and either extra-cerebral features (hyperechogenic bowel, hepato-splenomegaly, IUGR, ascites, placentitis, oligohydramnios, disseminated calcifications) or mild cerebral features (mild ventriculomegaly (10-12mm), isolated cyst of the germinal matrix) and biological parameters (viral load in amniotic fluid, fetal viremia and fetal platelets count).