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OP05 .02: Corroboration of normal and abnormal fetal cerebral lamination on postmortem sonography with neuropathological examination
Author(s) -
Pugash D.,
Dunham C. P.,
Mayer C.,
Hendson G.,
Gag A.
Publication year - 2013
Publication title -
ultrasound in obstetrics and gynecology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.202
H-Index - 141
eISSN - 1469-0705
pISSN - 0960-7692
DOI - 10.1002/uog.12754
Subject(s) - medicine , autopsy , fetus , lamination , pathology , subplate , anatomy , cerebral cortex , pregnancy , biology , chemistry , organic chemistry , layer (electronics) , genetics
Results Full ultrasound/autopsy correlation was available in 18 fetuses. In 8 fetuses with normal brains, cerebral lamination patterns were considered to be normal in all 7 cases in which full autopsy was performed. High frequency of ultrasound is correlated with 5 distinct sonographically identified histological layers on higher magnification views. Among 14 fetuses with abnormal prenatal intracranial findings, three patients declined autopsy; malformations were confirmed in all 3 on post-mortem sonography. In 2/11 fetuses undergoing full autopsy, findings were inconclusive due to autolysis. However, the antenatal findings were confirmed by postmortem ultrasound.