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First‐trimester uterine artery Doppler examination in pregnancies complicated by gestational diabetes mellitus with or without pre‐eclampsia
Author(s) -
Savvidou M. D.,
Syngelaki A.,
Balakitsas N.,
Panaiotova E.,
Nicolaides K. H.
Publication year - 2013
Publication title -
ultrasound in obstetrics and gynecology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.202
H-Index - 141
eISSN - 1469-0705
pISSN - 0960-7692
DOI - 10.1002/uog.12444
Subject(s) - medicine , obstetrics , gestational diabetes , interquartile range , uterine artery , eclampsia , gestation , pregnancy , gynecology , placentation , gestational age , incidence (geometry) , diabetes mellitus , fetus , placenta , endocrinology , physics , biology , optics , genetics
ABSTRACT Objectives To assess first‐trimester placental perfusion, reflected in the uterine artery ( UtA ) pulsatility index ( PI ), in pregnancies complicated by gestational diabetes mellitus ( GDM ), with or without pre‐eclampsia ( PE ), compared with those unaffected by GDM . Methods UtA‐PI was measured at 11 + 0 to 13 + 6 weeks' gestation in 1037 singleton pregnancies that subsequently developed GDM and in 56 649 normoglycemic controls. The measured mean UtA‐PI was converted to multiples of the expected normal median ( MoM ), corrected for maternal weight, racial origin and gestational age, and the median MoM values in the two groups were compared . Results The incidence of PE was higher in pregnancies with GDM than in controls (4.0% vs 2.3%, respectively ; P = 0.001). However, there were no significant differences in the median UtA‐PI MoM between the groups (1.00 (interquartile range ( IQR ), 0.82–1.21) vs 1.00 ( IQR , 0.81–1.21) ; P = 0.73). The median UtA‐PI in patients who developed PE was higher than in those who did not develop PE , regardless of the development of GDM . Conclusions First‐trimester placental perfusion, as assessed by UtA Doppler examination, is not impaired in women who subsequently develop GDM . The increased prevalence of PE in women with GDM cannot be attributed to impaired placentation. Copyright © 2013 ISUOG. Published by John Wiley & Sons Ltd .