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Polymicrogyria in a fetus with human parvovirus B19 infection: a case with radiologic–pathologic correlation
Author(s) -
Courtier J.,
Schauer G. M.,
Parer J. T.,
Regenstein A. C.,
Callen P. W.,
Glenn O. A.
Publication year - 2012
Publication title -
ultrasound in obstetrics and gynecology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.202
H-Index - 141
eISSN - 1469-0705
pISSN - 0960-7692
DOI - 10.1002/uog.11121
Subject(s) - polymicrogyria , medicine , parvovirus , fetus , prenatal ultrasound , pathology , prenatal diagnosis , autopsy , magnetic resonance imaging , parvoviridae , ventriculomegaly , obstetrics , pregnancy , radiology , immunology , biology , virus , genetics
We report the prenatal magnetic resonance imaging (MRI) appearance of polymicrogyria with pathologic correlation in a fetus with congenital parvovirus B19 infection. Prenatal ultrasound revealed non‐immune hydrops, but detected no fetal brain abnormalities. A subsequent fetal MRI scan performed at 23 weeks' gestation demonstrated bilateral polymicrogyria, which was confirmed at autopsy. To our knowledge, prenatal diagnosis of polymicrogyria in association with congenital parvovirus B19 infection has not been previously described. This case provides further evidence for brain abnormalities resulting from congenital parvovirus B19 infection, and suggests that fetal neuroimaging with MRI would be of value in suspected cases of congenital parvovirus infection. Copyright © 2012 ISUOG. Published by John Wiley & Sons, Ltd.