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Prospective evaluation of the IOTA logistic regression model LR2 for the diagnosis of ovarian cancer
Author(s) -
Nunes N.,
Yazbek J.,
Ambler G.,
Hoo W.,
Naftalin J.,
Jurkovic D.
Publication year - 2012
Publication title -
ultrasound in obstetrics and gynecology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.202
H-Index - 141
eISSN - 1469-0705
pISSN - 0960-7692
DOI - 10.1002/uog.11088
Subject(s) - medicine , logistic regression , ultrasound , receiver operating characteristic , ovarian cancer , gynecology , prospective cohort study , cancer , nuclear medicine , radiology
Objectives To assess the accuracy of the IOTA logistic regression model LR2 for the diagnosis of ovarian cancer. Methods This was a prospective single‐center study of women with an ultrasound diagnosis of an adnexal tumor. They were all examined by a single Level‐II ultrasound operator, who had received training in the systematic examination of ovarian tumors in accordance with the IOTA guidelines. In all women the likelihood of the adnexal lesion being malignant was calculated using the IOTA LR2 model. All women underwent surgery within 120 days of ultrasound examination and the ultrasound findings were compared with operative findings and the final histological diagnosis. Results One hundred and twenty‐four women were included in the final analysis. The mean age was 53.2 (range, 20–91) years and 61/124 (49.2%) women were postmenopausal. 66/124 (53.2%) women had malignant lesions on postoperative histological examination. The IOTA LR2 model had a sensitivity of 97.0% (95% CI, 89.5–99.6%) and a specificity of 69.0% (95% CI, 55.5–80.5%). The area under the receiver–operating characteristics curve was 0.93 (SE, 0.022; 95% CI, 0.89–0.97), which was not significantly different from 0.92 (SE, 0.018) reported in the original study (P > 0.05). Conclusion When evaluated prospectively, the accuracy of the IOTA LR2 model was similar to that reported in the original study. Copyright © 2012 ISUOG. Published by John Wiley & Sons, Ltd.