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Increased nuchal translucency, normal karyotype and infant development
Author(s) -
Miltoft C. B.,
Ekelund C. K.,
Hansen B. M.,
Lando A.,
Petersen O. B.,
Skovbo P.,
Jørgensen F. S.,
Sperling L.,
Zingenberg H.,
Nikkilä A.,
Shalmi A. C.,
Stornes I.,
Ersbak V.,
Tabor A.
Publication year - 2012
Publication title -
ultrasound in obstetrics and gynecology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.202
H-Index - 141
eISSN - 1469-0705
pISSN - 0960-7692
DOI - 10.1002/uog.10060
Subject(s) - medicine , percentile , fetus , gestational age , obstetrics , pregnancy , nuchal translucency , gestation , gynecology , first trimester , statistics , biology , genetics , mathematics
Objective To investigate whether chromosomally normal fetuses with a nuchal translucency (NT) ≥ 99 th percentile (3.5 mm) in the first trimester have an increased risk of delayed development at 2 years of age. Methods The study included children of women from 10 Danish hospitals who had fetal NT either ≥ 99 th percentile (Group 1) or < 95 th percentile (Group 2) in the first trimester. The groups were matched by gender, gestational age at birth and maternal age. There were twice as many children in Group 2 as in Group 1. Follow‐up was conducted at 2 years of age, infant development being assessed by the ‘Ages and Stages Questionnaire’. The cut‐off value for delayed development was defined as the 5 th percentile from the first 100 questionnaires from Group 2. Results In a 1‐year period 202 of 33 266 fetuses (0.6%) had NT ≥ 3.5 mm. Of these, 99 (49.0%) were liveborn with normal karyotype and normal ultrasound findings during pregnancy. The response rate to the ASQ was 83.3% in Group 1 and 71.4% in Group 2. A low ASQ score was found in 1.3% (1/80) and 4.4% (6/137) in Groups 1 and 2, respectively ( P = 0.265), but no difference was found in the mean ASQ score between the two groups ( P = 0.160). Conclusion Fetuses with NT ≥ 99 th percentile, normal karyotype and normal ultrasound findings during pregnancy had no increased risk of developmental delay at 2 years of age compared with fetuses with normal NT (< 95 th percentile). Copyright © 2011 ISUOG. Published by John Wiley & Sons, Ltd.