Open AccessThe acute and long‐term impact of physical activity on biochemical markers and MRI measures in osteoarthritis—Perspectives for clinical osteoarthritis research
Author(s) -
BjerreBastos Jonathan Jetsmark,
Karsdal Morten Asser,
Boesen Mikael,
Bliddal Henning,
BayJensen AnneChristine,
Andersen Jeppe Ragnar,
Bihlet Asger Reinstrup
Publication year - 2020
Publication title -
translational sports medicine
Language(s) - English
Resource type - Journals
ISSN - 2573-8488
DOI - 10.1002/tsm2.155
Subject(s) - osteoarthritis , medicine , magnetic resonance imaging , cartilage , articular cartilage , physical therapy , bioinformatics , pathology , radiology , alternative medicine , biology , anatomy
We aimed to investigate existing literature on the impact of physical activity and exercise (PA) on joint biochemical markers (BM) and magnetic resonance imaging (MRI) outcomes in osteoarthritis (OA), and on this basis propose directions for future research. Literature Review. Original papers were identified in PubMed, Embase, and Scopus and data on study populations, activity, biomarkers, imaging, and outcomes were extracted and reviewed. 24 papers, mainly on knee OA, were included. PA indicated acute increase in cartilage turnover in OA patients, as indicated by changes in markers of extra cellular matrix (ECM) turnover. Acute impact of PA on MRI outcomes in OA appears to constitute a gap in the literature, as only 1 study was identified. Long‐term effects of PA may be chondroprotective, judged from decreased serum BM. Studies of long‐term effects of PA on MRI measures showed various neutral, and both discrete positive and negative effects. Impact of PA on BM warrants further studies including information of potential coexisting inflammatory and structural changes on the joint level on MRI, in order to determine the significance of the BM findings. Development of a standardized method for clinical evaluation of BM dynamics following PA is warranted.