Open AccessPathobiology of the human prostate
Author(s) -
Maitland Norman J.
Publication year - 2008
Publication title -
trends in urology, gynaecology & sexual health
Language(s) - English
Resource type - Journals
eISSN - 1931-2288
pISSN - 1362-5306
DOI - 10.1002/tre.74
Subject(s) - prostatitis , prostate cancer , hyperplasia , prostate , medicine , disease , adenocarcinoma , cancer research , oncology , cancer , urology
Most disorders of the prostate are a result of a loss of essential growth control. The three main pathologies associated with this multifunctional but non‐essential gland – prostatitis, benign prostatic hyperplasia and adenocarcinoma – are thought to originate in the central, transitional and peripheral zones, respectively. Professor Maitland outlines factors that affect the development of prostate cancer and discusses the stem cell hypothesis, which provides explanations for the relative resistance of the tumours to most types of conventional therapy, and for the presence of residual disease after androgen therapy. Copyright © 2008 Wiley Interface Ltd