Open AccessA pragmatic dementia risk score for patients with mild cognitive impairment in a memory clinic population: Development and validation of a dementia risk score using routinely collected data
Author(s) -
Wang Meng,
Sajobi Tolulope T.,
Ismail Zahinoor,
Seitz Dallas,
Chekouo Thierry,
Forkert Nils D.,
Fischer Karyn,
Mackie Aaron,
Pearson Dawn,
Patry David,
Cieslak Alicja,
Me Bijoy,
Barber Philip,
McLane Brienne,
Granger Robert,
Hogan David B.,
Smith Eric E.
Publication year - 2022
Publication title -
alzheimer's and dementia: translational research and clinical interventions
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.49
H-Index - 30
ISSN - 2352-8737
DOI - 10.1002/trc2.12301
Subject(s) - dementia , confidence interval , medicine , population , cognitive impairment , disease , environmental health
This study aimed to develop and validate a 3‐year dementia risk score in individuals with mild cognitive impairment (MCI) based on variables collected in routine clinical care. Methods The prediction score was trained and developed using data from the National Alzheimer's Coordinating Center (NACC). Selection criteria included aged 55 years and older with MCI. Cox models were validated externally using two independent cohorts from the Prospective Registry of Persons with Memory Symptoms (PROMPT) registry and the Alzheimer's Disease Neuroimaging Initiative (ADNI) database. Results Our Mild Cognitive Impairment to Dementia Risk (CIDER) score predicted dementia risk with c‐indices of 0.69 (95% confidence interval [CI] 0.66–0.72), 0.61 (95% CI 0.59–0.63), and 0.72 (95% CI 0.69–0.75), for the internally validated and the external validation PROMPT, and ADNI cohorts, respectively. Discussion The CIDER score could be used to inform clinicians and patients about the relative probabilities of developing dementia in patients with MCI.