Open AccessMoyamoya disease: A human model for chronic hypoperfusion and intervention in Alzheimer's disease
Author(s) -
Zou Xiang,
Yuan Yifan,
Liao Yujun,
Jiang Conglin,
Zhao Fan,
Ding Ding,
Gu Yuxiang,
Chen Liang,
Chu YingHua,
Hsu YiCheng,
Liebig Patrick Alexander,
Xu Bin,
Mao Ying
Publication year - 2022
Publication title -
alzheimer's and dementia: translational research and clinical interventions
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.49
H-Index - 30
ISSN - 2352-8737
DOI - 10.1002/trc2.12285
Subject(s) - cerebral hypoperfusion , etiology , moyamoya disease , disease , medicine , pathological , alzheimer's disease , perfusion , cardiology , senile plaques , neuroscience , pathology , psychology
Chronic cerebral hypoperfusion has been considered the etiology for sporadic Alzheimer's disease (AD). However, no valid clinical evidence exists due to the similar risk factors between cerebrovascular disease and AD. Methods We used moyamoya disease (MMD) as a model of chronic hypoperfusion and cognitive impairment, without other etiology interference. Results Based on the previous reports and preliminary findings, we hypothesized that chronic cerebral hypoperfusion could be an independent upstream crucial variable, resulting in AD, and induce pathological hallmarks such as amyloid beta peptide and hyperphosphorylated tau accumulation. Discussion Timely intervention with revascularisation would help reverse the brain damage with AD hallmarks and lead to cognitive improvement.