Open AccessLongitudinal naming and repetition relates to AD pathology and burden in autopsy‐confirmed primary progressive aphasia
Author(s) -
Cousins Katheryn A.Q.,
Bove Jessica,
Giannini Lucia A. A.,
Kinney Nikolas G.,
Balgenorth Yvonne R.,
Rascovsky Katya,
Lee Edward B.,
Trojanowski John Q.,
Grossman Murray,
Irwin David J.
Publication year - 2021
Publication title -
alzheimer's and dementia: translational research and clinical interventions
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.49
H-Index - 30
ISSN - 2352-8737
DOI - 10.1002/trc2.12188
Subject(s) - primary progressive aphasia , repetition (rhetorical device) , boston naming test , audiology , frontotemporal lobar degeneration , psychology , aphasia , cognitive decline , cognition , autopsy , alzheimer's disease , medicine , pathology , neuroscience , disease , dementia , frontotemporal dementia , neuropsychology , linguistics , philosophy
In primary progressive aphasia (PPA) patients with autopsy‐confirmed Alzheimer's disease (AD) or frontotemporal lobar degeneration (FLTD), we tested how the core clinical features of logopenic PPA—naming and repetition—change over time and relate to pathologic burden. Methods In PPA with AD (n = 13) or FTLD (n = 16) pathology, Boston Naming Test and Forward Digit Span measured longitudinal naming and repetition; as reference, Mini‐Mental State Examination (MMSE) measured global cognition. Pathologic burden in left peri‐Sylvian regions was related to longitudinal cognitive decline. Results PPA with AD showed greater decline in naming ( P = 0.021) and repetition ( P = 0.020), compared to FTLD; there was no difference in MMSE decline ( P = 0.99). Across all PPA, declining naming ( P = 0.0084) and repetition ( P = 0.011) were associated with angular, superior‐middle temporal (naming P = 0.014; repetition P = 0.011) and middle frontal (naming P = 0.041; repetition P = 0.030) pathologic burden. Discussion Unique longitudinal profiles of naming and repetition performance in PPA with AD are related to left peri‐Sylvian pathology.