Open AccessDevelopment and validation of language and visuospatial composite scores in ADNI
Author(s) -
Choi SeoEun,
Mukherjee Shubhabrata,
Gibbons Laura E.,
Sanders R. Elizabeth,
Jones Richard N.,
Tommet Douglas,
Mez Jesse,
Trittschuh Emily H.,
Saykin Andrew,
Lamar Melissa,
Rabin Laura,
Foldi Nancy S.,
Sikkes Sietske,
Jutten Roos J.,
Grandoit Evan,
Mac Donald Christine,
Risacher Shan,
Groot Colin,
Ossenkoppele Rik,
Crane Paul K.
Publication year - 2020
Publication title -
alzheimer's and dementia: translational research and clinical interventions
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.49
H-Index - 30
ISSN - 2352-8737
DOI - 10.1002/trc2.12072
Subject(s) - neuroimaging , psychology , cognition , alzheimer's disease neuroimaging initiative , biomarker , dementia , cognitive impairment , audiology , disease , neuroscience , medicine , biochemistry , chemistry
Composite scores may be useful to summarize overall language or visuospatial functioning in studies of older adults. Methods We used item response theory to derive composite measures for language (ADNI‐Lan) and visuospatial functioning (ADNI‐VS) from the cognitive battery administered in the Alzheimer's Disease Neuroimaging Initiative (ADNI). We evaluated the scores among groups of people with normal cognition, mild cognitive impairment (MCI), and Alzheimer's disease (AD) in terms of responsiveness to change, association with imaging findings, and ability to differentiate between MCI participants who progressed to AD dementia and those who did not progress. Results ADNI‐Lan and ADNI‐VS were able to detect change over time and predict conversion from MCI to AD. They were associated with most of the pre‐specified magnetic resonance imaging measures. ADNI‐Lan had strong associations with a cerebrospinal fluid biomarker pattern. Discussion ADNI‐Lan and ADNI‐VS may be useful composites for language and visuospatial functioning in ADNI.