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Effect of long‐term exposure to aluminum and high‐fat diet on NTPDase and 5′‐nucleotidase activities in lymphocytes and platelets of rats
Author(s) -
Kaizer Rosilene Rodrigues,
Costa Eduarda,
Andrade Cínthia Melazzo,
Schmatz Roberta,
Gutierres Jessié Martins,
Martins Danieli Brolo,
Morsch Vera Maria,
Schetinger Maria Rosa Chitolina
Publication year - 2017
Publication title -
environmental quality management
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.249
H-Index - 27
eISSN - 1520-6483
pISSN - 1088-1913
DOI - 10.1002/tqem.21507
Subject(s) - platelet , downregulation and upregulation , immune system , 5' nucleotidase , nucleotidase , inflammation , immunology , endocrinology , biology , chemistry , medicine , adenosine , biochemistry , gene
Aluminum is one of the most abundant metals in the earth's crust. Although it shows no known biological function, it is recognized as an adjuvant in vaccines for human and veterinary uses. This study aims to evaluate the role of lifestyle and environment in the promotion of chronic disease. In it, we associated two factors: chronic exposure to aluminum and high‐fat diets. Thus, we aimed to determine whether the association of long‐term exposure to aluminum and high‐fat diets affects the NTPDase and 5′‐nucleotidase activities in the blood platelets and lymphocytes obtained from the mesenteric lymph nodes of young rats. In fact, the ectonucleotidase activities were shown to be upregulated upon exposure to aluminum plus high‐fat diets. As a result, we can suggest that the progressive upregulation of ectonucleotidase activities that we observed could be controlling the extent of inflammation and immune response.