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Maternal perinatal exposure to bisphenol S induces an estrogenic like effect in glucose homeostasis in male offspring
Author(s) -
Morimoto Sumiko,
SolísLemus Edgar,
JiménezVivanco Jesica,
CastellanosRuiz Dafne,
DíazDíaz Eulises,
MendozaRodríguez C. Adriana
Publication year - 2022
Publication title -
environmental toxicology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.813
H-Index - 77
eISSN - 1522-7278
pISSN - 1520-4081
DOI - 10.1002/tox.23585
Subject(s) - endocrinology , medicine , offspring , glucose homeostasis , homeostasis , lactation , carbohydrate metabolism , biology , type 2 diabetes mellitus , bisphenol s , pregnancy , diabetes mellitus , insulin , testosterone (patch) , impaired glucose tolerance , type 2 diabetes , insulin resistance , bisphenol a , chemistry , organic chemistry , epoxy , genetics
Bisphenol S (BPS) has been introduced into the industry as a safer alternative to bisphenol A (BPA). However, the recent studies have reported a possible association between BPS and disturbed glucose homeostasis, indicating that it may be a risk factor for type 1 and type 2 diabetes mellitus, obesity, and gestational diabetes mellitus. Nevertheless, the role of BPS in glucose metabolism remains controversial. In this study, we investigated the glucose metabolism of male Wistar rats born from dams that were BPS‐exposed (groups: BPS‐L (0.05 mg/kg/day), BPS‐H (20 mg/kg/day)) during pregnancy and lactation. We observed that both BPS treated groups of animals presented a significant decrease in anogenital distance/weight 1/3 , as compared to control animals, although no alterations in testosterone levels were observed. Furthermore, the BPS‐L group presented a significant decrease in body weight from postnatal day (PND) 21 to adult stage. In addition, a significant increase in glucose tolerance, pancreatic β‐cell proliferation, the frequency of small islets, and the average β‐cell size at PND 36 was observed in this group. However, no changes in insulin serum levels and percentage of β‐cells were recorded. Furthermore, these changes were not preserved at the adult stage (PND 120). The results suggest that the administration of low doses of BPS during the perinatal period induced an estrogenic like effect, with males apparently becoming more female‐like in their responses to a glucose challenge.